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Loss of cell identity drives human aging: Two new papers

369 points · 184 comments · bookofjoe

  1. dyauspitr · · focus · HN ↗
    So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.

    Do we currently have the ability to do targeted methylation or de methylation at sites in cells?

    1. sajithdilshan · · focus · HN ↗
      I was thinking maybe some chemicals can help with chronic stress, but then again it would be more like a plaster than addressing the root cause.

      I guess the only permanent fix for stress in modern days is having enough money so one wouldn’t have to worry about it. As a single person I cannot think of any scenario where money cannot relieve my stress

      1. K0balt · · focus · HN ↗
        Problem is that just feeds the problematic paradigm. We need to be thinking carefully. Money, ultimately, is only used to pay wages. Nothing else. Resources and energy are never paid for, only labor, directly or indirectly.

        So we need to consider, what are we paying for that doesn’t translate efficiently to labor? What are we paying for that is merely the externalitization of costs? Of legislative capture so that otherwise communal resources can be monetised? Rent extraction from community created commons?

        There are reasons that modern humans spend much more of their time struggling to make ends meet than primitive humans, and a reason why people live much more comfortably with less struggle and a better life balance in some countries versus others. Money is incredibly useful, but it also serves to hide unjust and inequitable mechanisms that create perverse incentives that create a situation where every shred of excess value that a person sheds becomes mandatory just to keep your head above water, creating a condition of eternal struggle up to the absolute limit of endurance if you allow yourself to follow the dots on the floor.

        Obviously looking up and looking around, subverting the dominant paradigm, and eschewing “what you are supposed to do(c) “ can work, with risks, but perhaps it’s time to question whether the unrestricted amassing of resources by a few at the expense of everyone else is the right answer to the situations we are confronting?

        Idk, crazy talk, right?

        1. sajithdilshan · · focus · HN ↗
          You're over analysing it. If I didn't have to worry about money, I would just book a vacation in Italy and that would completely take my stress away
          1. pasquinelli · · focus · HN ↗
            i bet it wouldn't.

            you'd probably get sick on vacation and make your situation worse by obsessing over how you wish you weren't sick, in exactly the same way that you now obsess over how you wish you had more money than you do.

            1. sajithdilshan · · focus · HN ↗
              I disagree, I cannot explain it, but I’m always healthy and happy and worry free whenever I’m in Italy
              1. pasquinelli · · focus · HN ↗
                do you live close to italy?

                if not, then you must have a lot of money to have visited multiple times.

            2. sampullman · · focus · HN ↗
              I got sick on the flight during my last vacation, but I'd splurged on business class so it was still awesome. Took some Tylenol the next couple days and had a fantastic time.

              No need to stress about money either, as long as you have enough to cover your basic needs, and live in a country with universal healthcare.

      2. pasquinelli · · focus · HN ↗
        i think you're mixing up psychological stress and cellular stress.

        as for psychological stress, you will never have enough of anything, or be free enough from anything, or any combination, to be safe from stress.

        1. sajithdilshan · · focus · HN ↗
          I get what you mean. Human greed has no bounds. But if one can really discipline themselves then I think it’s possible to be stress free with proper planning and money
          1. pasquinelli · · focus · HN ↗
            yeah maybe, but regardless you'll still have pretty close to the same load of, like, biomolecular stress that causes aging.
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