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Why is the liver so weirdly regenerative?

576 points · 293 comments · jbotz

  1. Aeolun · · focus · HN ↗
    I feel like this is obvious. Eventually dying of all the weird body failures doesn’t inhibit your ability to procreate, but if you cannot survive alcohol or other various poisons you’ll never make it to a fertile age.
    1. nomel · · focus · HN ↗
      Picking the wrong berry from a bush isn't so difficult. Ask me how I know. And, for my second encounter, don't think because you see an animal eating it, it's safe!
      1. cratermoon · · focus · HN ↗
        Did you know birds do not have receptors for capsaicin? They can eat any pepper and it doesn't affect them. So if you see a bird snacking on a pepper that's red or greenish-yellow, wrinkly, and has a pointy end, well ... watch out
      2. colechristensen · · focus · HN ↗
        And onions are mildly toxic to cats and dogs. There is a lot less shared responses as to what is toxic or edible across species.

        Basically every flavor compound in an herb or spice we eat is a poison directed at insects, microbes, or other creatures. (much less every medicinal or psychoactive compound found in nature)

        1. hobo123 · · focus · HN ↗
          Onion compounds slow down ALDH (aldehyde detox), not sure if for cats it's a different (i.e. yet another) mechanism though.
      3. Aeolun · · focus · HN ↗
        Doesn’t that validate my point? The liver needs to deal with this stuff unless you manage to throw it all up again.
        1. nomel · · focus · HN ↗
          Not all responses are a counterarguments. That one was very clearly supporting, anecdotal, evidence.
    2. kypro · · focus · HN ↗
      My guess is that this is half the story. It seems like there would be some advantage to some creatures of not aging, or having individuals who have significant longer life spans.

      This is common in evolutionary algorithms anyway so it's notable we don't see it in nature, at least not in the form of extended lifespan perhaps measured by average lifetime heart beats. It's easy to imagine a world where nature might want to keep the alpha lion around longer than the others so it can have more offspring, for example.

      1. colechristensen · · focus · HN ↗
        >It seems like there would be some advantage to some creatures of not aging, or having individuals who have significant longer life spans.

        There is, if there were no advantage a whole lot more species would die immediately after reproduction like the octopus.

        Many simpler organisms are vaguely immortal.

        >It's easy to imagine a world where nature might want to keep the alpha lion around longer than the others so it can have more offspring, for example.

        The utility of genetic diversity puts a lot of pressure against this.

        1. kypro · · focus · HN ↗
          > There is, if there were no advantage a whole lot more species would die immediately after reproduction like the octopus.

          I didn't just meant extending lifespan, I meant extending the time an individual is fertile.

          > The utility of genetic diversity puts a lot of pressure against this.

          High levels of elitist selection lowers diversity and can have a negative impact on a population's adaptive ability, but there is a sweet spot to diversity. Maximally diverse is just noise after all.

          A small amount of elitism is generally what you would expect to be selected for, and we certainly see this other forms in most creatures, but never in the form of extended life span. That makes me suspect there's probably something fundamentally difficult about extending an organism's lifespan given our biological architecture and that's why evolution has favoured other forms of elitist selection.

    3. nofunsir · · focus · HN ↗
      It's more than possible to make it to adulthood without ingesting a drop of alcohol, even if you're talking about fermented fruit. It's easy, in fact.
      1. Muromec · · focus · HN ↗
        This right here is religious propaganda
      2. fahrvrgnugen · · focus · HN ↗

        [dead]

    4. westurner · · focus · HN ↗
      Adaptation hypothesis: rotting fruit ferments, fermented water is cleaner, and overconsumption and liver failure lead to falling out of the tree.
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