Thread

1. krisroadruck · 1790993093 · focus · HN ↗

   Reporting on these drugs is so bad. Most of the benefits AND downsides they keep reporting are the same for any major rapid weight loss. Be it hair shedding or sleep apnea resolving. They keep acting like these are novel drug specific side effects rather than weight-loss related side effects.

   1. Barrin92 · 1790993383 · focus · HN ↗

      if you're losing it as a weight loss drug and that's a side effect of the rapid weight loss that otherwise wouldn't occur it's a side effect of the drug in any practical sense, or are you trying to establish the 'guns don't kill people' for pharmaceuticals?

      It's a side effect of the treatment regimen that many people in all likelihood aren't even aware of so it's good to report it like this

      1. mbirth · 1790994023 · focus · HN ↗

         If you’re drunk and bump your head into a lantern, would you say that haematomas are a side-effect of alcohol consumption?

         1. gumby · 1790994349 · focus · HN ↗

            FDA trials follow this approach. If something bad happens it’s logged as an adverse event; if they croak it’s a serious adverse event (SAE).

            So if you have a treatment for moles, and a patient (trial participant) has a mole on their back treated and then falls down the stairs or is run over by a trolley the agency wants you to do an analysis to see if the treatment might have had something to do with getting run over or not taking the lift.

            Note: this is not an exaggeration. I have written phase I and phase II clinical trial protocols earlier in my career.

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