Loss of cell identity drives human aging: Two new papers
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Loss of cell identity drives human aging: Two new papers
Unofficial Hacker News client; not affiliated with Y Combinator.
dyauspitr · · focus · HN ↗
Do we currently have the ability to do targeted methylation or de methylation at sites in cells?
SlightlyLeftPad · · focus · HN ↗
[0]: <a href="https://www.forbes.com/sites/tracybrower/2024/09/15/how-being-hopeful-reduces-stress/" rel="nofollow">https://www.forbes.com/sites/tracybrower/2024/09/15/how-bein...
amelius · · focus · HN ↗
missedthecue · · focus · HN ↗
I think the former group almost certainly outweighs the latter group at least in the Western hemisphere, but I know the Western hemisphere has been steeped in a deep malaise of anti-optimism for several decades preceding AI to begin with. That it's almost a game to identify all the ways anything new might be bad, rather than celebrating the obvious ways they are good. And this penchant invariably biases their developing opinions of all new technology, be it AI or anything else.
DennisP · · focus · HN ↗
Space, nuclear fusion, advanced fission, the internet since about 1993, blockchain, anti-aging, I've been a big fan of all of it. But I've read the AI safety arguments and seen what a lot of researchers say about it, and I'm seriously worried.
sfn42 · · focus · HN ↗
And then there's fears that someone might use it to engineer a super virus or something like that, which isn't really a new worry. People could do that before too, but it turns out creating a global epidemic isn't really a thing very many people want to do, and it's harder than most people imagine.
"AI" are just chatbots. They can't fabricate robots to take over the world, in fact they have very limited reach into the real world altogether. Sure maybe you could envision some kind of malicious hacking, sabotaging some industrial control system to create a disaster of some kind or whatever but that was a worry before AI too which is why most critical systems like this are air gapped and have safety mechanisms.
So I really just don't understand how people think AI will destroy the world. And I think its especially frustrating to see all this energy going into AI-related despair when climate change actually is on the brink of actually destroying the world in a completely real and concrete way, but most people don't give a shit about that. Some people will say it's natural cycles or some other variant of denying the problem, others will say it's not a big deal, yet others will say science will solve it, we'll capture the carbon or spray aerosols into the atmosphere to stop the warming etc.
And they're all wrong. It's not natural cycles - shocker, climate scientists know about natural cycles. It is a huge deal. We're at +1.5c now and it's already having huge compounding effects. Warming is accelerating, we'll likely be at +3c in just a few decades. That is already approaching apocalyptic levels of warming.
Carbon capture is a joke, there is absolutely no way carbon capture solves climate change. We would need tens or hundreds of thousands of carbon capture facilities all over the globe, it would be the largest engineering project in history by orders of magnitude. There would be many times more capture facilities than power plants. Nevermind the energy, concrete, chemicals etc required to build and run all of them, not to mention actually deal with all that carbon they would be capturing. It's not feasible.
Climate engineering would be highly experimental, and it would also be a gargantuan project requiring enormous economic investment. It would likely have huge unintended consequences, and it might not even work. It might also have different consequences for different nations creating huge political issues - what if a country does climate engineering that's good for them but disastrous for their neighbours? Is it even possible to do climate engineering in a way that isn't bad for someone? Is it even possible/feasible to do it on the scale necessary to actually combat global warming?
Yeah I don't know why people are panicking about AI, if there's anything you should be panicking about it's global warming.
jodrellblank · · focus · HN ↗
1. If it never happens or AGI is friendly then we won't need to. If a hostile AGI is created, one trained on all writing about war and strategy and deception, able to respond in microseconds, with has ample time to plot before it makes an obvious move, then thinking you will wait until you see it attack and then turn off a datacenter, is way too little, too late. Like saying "the nuclear bomb explosion is local to one place, if it hurts, we will just walk away from it".
2. That claim does not hold water once you start to dig into who, specifically, would turn off which specific billion-dollar datacenter, under which conditions. Google has been moving compute jobs around the planet to get nighttime electricity rates for bulk compute jobs for years, the idea that there is "one datacenter" is far too simple. The idea that employee 74,123 at Meta doing AI research is also able to get a Meta datacenter shutdown quickly on request, or would know enough about Meta's infrastructure to know which datacenter, seems unlikely. The idea that it even has one off switch, or that nobody will quickly power it back on, or that the compute jobs will not pick up automatically somewhere else, or that nobody else on the planet will be at a similar point in their research, also seem important.
3. This assumes there will be a simple critical point that makes it clear we need to "turn off datacenter now". The fact that you then go on to talk about climate change, imagine you had said "we can just turn the factories off if climate change becomes a problem" and maybe that will make it clearer. Who will turn which factories off, at what point in the climate catastrophe, and why haven't they? That's why it won't happen with datacenters either.
> "Like we're not going to have some runaway skynet thing, that's just completely off the table."
You're confident that tens of billions of dollars of investment and research, US v China national AI competition, some of the largest companies in the world researching AGI will be a flop and develop nothing? Despite the progress from GPT2 to present day, despite historic analogies like the Wright Brothers to the Moon Landing in one lifetime?
NVidia shipped an estimated 40 million GPUs in 2025. Say they average 1 TFLOPS each and a year has 31 million seconds, that's 1.2 million million quadrillion calculations in a year. That much compute power piling up around the planet year-on-year is not going to be important or relevant to the near-medium term future? Because it's just "off the table" that anyone could invent anything interesting with that much growing compute in the next ten or twenty years?
lofaszvanitt · · focus · HN ↗
jodrellblank · · focus · HN ↗
Now are you imagining that the employee who can’t ask for a data centre to be shut down, can call the military and telling them a self-improving AGI is about to destroy the world and they need to attack an American company?
lofaszvanitt · · focus · HN ↗