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Loss of cell identity drives human aging: Two new papers

369 points · 184 comments · bookofjoe

  1. dyauspitr · · focus · HN ↗
    So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.

    Do we currently have the ability to do targeted methylation or de methylation at sites in cells?

    1. everdrive · · focus · HN ↗
      I just don't understand. Wouldn't we have evolved in an environment with constant stress? Constant fear of disease, starvation, predation, attacks by neighboring tribes? Why would our body's natural response to our environment be to immediately grenade itself.
      1. atiedebee · · focus · HN ↗
        Considering that aging only happens later in life, it wouldn't have much of an effect on how efficient humans produce offspring, so it wouldn't be selected against. It is the same explanation for why Huntington's and Alzheimer's are still around.
        1. zorobo · · focus · HN ↗
          > Considering that aging only happens later in life,

          In other news, widows outlive their husbands.

          1. someonebaggy · · focus · HN ↗
            We are not talking about your amount of time on earth going up, we are talking about the biological mechanisms that happen later in life.
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