Thread

1. rotbart · 1791018164 · focus · HN ↗

   The strongest evidence we have of the reversibility of epigenetic aging, as well as its limitations -- are embryos which undergo an epigenetic reset.

   After fertilisation, the embryo strips the father's DNA of its age-linked chemical tags and swaps its packaging, destroys his mitochondria, rebuilds telomeres, and clears damaged proteins, though it can't undo the DNA mutations sperm gather as men age.

   (those that result in an non viable embryo result in miscarriage.)

   1. darkerside · 1791021494 · focus · HN ↗

      Hmmm seems high stakes

      1. dzonga · 1791030535 · focus · HN ↗

         pregnancies are high stakes.

         it's actually surprising they happen at all given the very low probability of everything going right.

         1. le-mark · 1791061424 · focus · HN ↗

            > very low probability of everything going right.

            Looking around at 8 billion+ people on this planet, is the probability that low?

            1. mitxela · 1791110064 · focus · HN ↗

               It's about the same as the probability that your computer happens to only execute valid instructions.

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