‹ BackHN Continuity

Thread

Loss of cell identity drives human aging: Two new papers

369 points · 184 comments · bookofjoe

  1. dyauspitr · · focus · HN ↗
    So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.

    Do we currently have the ability to do targeted methylation or de methylation at sites in cells?

    1. SlightlyLeftPad · · focus · HN ↗
      Good news! Research shows that hope reduces stress! [0]

      [0]: <a href="https:&#x2F;&#x2F;www.forbes.com&#x2F;sites&#x2F;tracybrower&#x2F;2024&#x2F;09&#x2F;15&#x2F;how-being-hopeful-reduces-stress&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.forbes.com&#x2F;sites&#x2F;tracybrower&#x2F;2024&#x2F;09&#x2F;15&#x2F;how-bein...

      1. amelius · · focus · HN ↗
        Sadly, AI just made many of us lose all hope.
        1. missedthecue · · focus · HN ↗
          AI is an amazing Rorschach test in this regard. In the way that two people will look at it -- not just AI in general but in a specific implementation of it (coding, vidgen, etc). And one will feel deep dread and knots in their stomach while the other is filled to the brim with hope and optimism.

          I think the former group almost certainly outweighs the latter group at least in the Western hemisphere, but I know the Western hemisphere has been steeped in a deep malaise of anti-optimism for several decades preceding AI to begin with. That it&#x27;s almost a game to identify all the ways anything new might be bad, rather than celebrating the obvious ways they are good. And this penchant invariably biases their developing opinions of all new technology, be it AI or anything else.

          1. kakacik · · focus · HN ↗
            Sure if you work in anthropic &#x2F; openai or several connected &#x2F; similar places future is exciting. And that&#x27;s about it for the list, over-represented on HN but not really out there in real world.

            Literally everybody else, all white collars including, feels they could be replaced in 5-10 years. Just talk to people ffs, its not that hard. Literally everybody is worried, doctors (know plenty from all parts of medical care), lawyers, bankers, tons of various bureaucrats, ALL are afraid in one way or another. Its also sort of helpless worry you have 0 control of, not very nice place to be 24&#x2F;7 in the back of one&#x27;s mind. Double that for parents with non-teen kids.

            I use nature to relax and recharge and it works wonders. But reality is as it is and I have 2 small kids, I don&#x27;t expect to hold the job I have in next 5 years, maybe due to llms maybe not. But I will have big issues finding another job on over-saturated market at that point, thats completely on llms. Thus as any sane person, hating the tool destroying my&#x2F;our future while using it from time to time (in minimal fashion, code churning is really not a bottleneck in any decently large company and certainly not mine but I can imagine code sweatshops doing various cruds and eshops all day can be much faster now).

Open on Hacker News to reply ↗

Unofficial Hacker News client; not affiliated with Y Combinator.