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Loss of cell identity drives human aging: Two new papers

369 points · 184 comments · bookofjoe

dyauspitr · 1790966547 · focus · HN ↗
So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.
Do we currently have the ability to do targeted methylation or de methylation at sites in cells?
1. SlightlyLeftPad · 1790967259 · focus · HN ↗
  Good news! Research shows that hope reduces stress! [0]
  [0]: <a href="https://www.forbes.com/sites/tracybrower/2024/09/15/how-being-hopeful-reduces-stress/" rel="nofollow">https://www.forbes.com/sites/tracybrower/2024/09/15/how-bein...
  1. amelius · 1790968161 · focus · HN ↗
    Sadly, AI just made many of us lose all hope.
    missedthecue · 1790983058 · focus · HN ↗
    AI is an amazing Rorschach test in this regard. In the way that two people will look at it -- not just AI in general but in a specific implementation of it (coding, vidgen, etc). And one will feel deep dread and knots in their stomach while the other is filled to the brim with hope and optimism.
    I think the former group almost certainly outweighs the latter group at least in the Western hemisphere, but I know the Western hemisphere has been steeped in a deep malaise of anti-optimism for several decades preceding AI to begin with. That it's almost a game to identify all the ways anything new might be bad, rather than celebrating the obvious ways they are good. And this penchant invariably biases their developing opinions of all new technology, be it AI or anything else.
    Morromist · 1791005597 · focus · HN ↗
    AI would be much easier to be optimistic about if it were in the hands of people I like and trust. Its in the hands of people who appear to be complete psychopaths instead.
    missedthecue · 1791010996 · focus · HN ↗
    On the other hand I'm amazed at how flat access is. Access to the best models available is incredibly inexpensive relative to technology in the past, and everyone in the world with at least a smartphone has access to an LLM of some sort now.
    Second, the technology is very open. It's not as if the ONLY way to access an LLM is to pay a toll to Sam Altman. Models that are very good can run on my Macbook for the price of electricity and they're only getting better.

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