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Loss of cell identity drives human aging: Two new papers

369 points · 184 comments · bookofjoe

  1. dyauspitr · · focus · HN ↗
    So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.

    Do we currently have the ability to do targeted methylation or de methylation at sites in cells?

    1. everdrive · · focus · HN ↗
      I just don't understand. Wouldn't we have evolved in an environment with constant stress? Constant fear of disease, starvation, predation, attacks by neighboring tribes? Why would our body's natural response to our environment be to immediately grenade itself.
      1. dyauspitr · · focus · HN ↗
        I don’t think humans evolved under chronic stress conditions. I think we evolved under momentary stress conditions. Also stresses are heavily mitigated by community and our current society is generally one of chronic stress and low social connections. Inducing a moderate level of stress in your employees is literally the primary “motivational” tool for management in most places.
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