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Loss of cell identity drives human aging: Two new papers

369 points · 184 comments · bookofjoe

dyauspitr · 1790966547 · focus · HN ↗
So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.
Do we currently have the ability to do targeted methylation or de methylation at sites in cells?
1. everdrive · 1790972335 · focus · HN ↗
  I just don't understand. Wouldn't we have evolved in an environment with constant stress? Constant fear of disease, starvation, predation, attacks by neighboring tribes? Why would our body's natural response to our environment be to immediately grenade itself.
  1. Lichtso · 1790972688 · focus · HN ↗
    There always has been a lot of stress, but there used to be relaxed moments as well. The issue is that we don't calm down anymore.
    Relevant video by Kurzgesagt – In a Nutshell: <a href="https://www.youtube.com/watch?v=Mo1A45ShcMo" rel="nofollow">https://www.youtube.com/watch?v=Mo1A45ShcMo
    someonebaggy · 1791032371 · focus · HN ↗
    That's a private equity AI slop channel. Any other reference?
    unfitted2545 · 1791045056 · focus · HN ↗
    <a href="https://en.wikipedia.org/wiki/Why_Zebras_Don%27t_Get_Ulcers" rel="nofollow">https://en.wikipedia.org/wiki/Why_Zebras_Don%27t_Get_Ulcers
    Sapolsky goes into great detail about the positive affects of stress in short durations, then demonstrates how these positives turn into negatives all over our body after being stressed for too long. Highly recommend!

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