Thread

1. pazimzadeh · 1790701650 · focus · HN ↗

   Seems par for the course since our adaptive immune system is based on an old viral/transposon recombinase.

   Transposon Molecular Domestication and the Evolution of the RAG Recombinase

   <a href="https:&#x2F;&#x2F;pmc.ncbi.nlm.nih.gov&#x2F;articles&#x2F;PMC6494689&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pmc.ncbi.nlm.nih.gov&#x2F;articles&#x2F;PMC6494689&#x2F;

   Here is the actual study:

   Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates

   <a href="https:&#x2F;&#x2F;www.science.org&#x2F;doi&#x2F;10.1126&#x2F;science.aeh3441" rel="nofollow">https:&#x2F;&#x2F;www.science.org&#x2F;doi&#x2F;10.1126&#x2F;science.aeh3441

   1. shevy-java · 1790716277 · focus · HN ↗

      Is VDJ recombination based on viruses or transposons?

      It&#x27;s the first time I hear this. Can&#x27;t yet say much about it until I can verify that.

      1. pazimzadeh · 1790728561 · focus · HN ↗

         Yes, the RAG transposon inserted itself into a variable domain exon about 500 million years ago. Here’s a more recent paper on this:

         Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon

         <a href="https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;40614193&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;40614193&#x2F;

         &gt; It&#x27;s the first time I hear this. Can&#x27;t yet say much about it until I can verify that.

         How are you going to verify it?

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