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Creatine uptake enhances antitumor immunity

185 points · 227 comments · lormayna

  1. MarkusWandel · · focus · HN ↗
    I started taking a scoop of the Creatine Hydrate from Costco every afternoon because why not. Wife had bought it and the bag was sitting right there.

    I honestly don't know whether it made a difference. Sleep didn't get worse, no noticeable metabolic effects. Possibly the "perma tired muscles" I've been suffering from increasingly since about age 57 (I'm an active cyclist) have gotten a bit better, with <50% of days affected rather than >90% last year, but even that is subjective.

    If "taking the stuff" means "more uptake" (does it?) and there are other beneficial effects, bring it on.

    1. j45 · · focus · HN ↗
      Creatine is one of the most studied supplements.

      It sounds you have the hardest part of it underway - consistency.

      There's lots of studies - if you can get over 20g per day it is noticeable to the brain and energy. Adding a few grams a week until you're up there I found it noticeable. 20-30g seems to be a noticeable range.

      Supplements aren't always like a coffee spike, they build up and sustain quite well.

      1. Yajirobe · · focus · HN ↗
        I thought around 5g is the recommended daily dose?
        1. kenhwang · · focus · HN ↗
          20g is a loading dose (typically for a week), then it's 3-5g daily for maintenance. But I've seen studies that 5g daily catches up to the 20g loading dose after about a month.
          1. swozey · · focus · HN ↗
            I've taken creatine for 20+ years, nobody does the "loading" dose anymore, or shouldn't be if they still do. Maybe it stills says it on the jars but there was tons of information a decade or more ago that it was deemed as a way to get you to blast through your jug faster. 5g is the normal dose. You're always taking in creatine eating normal meat added meals.

            This is giving me flashbacks to using bodybuilding.com forums.. man, long time ago.

            It is my 100% always buy supplement. I only have 2 of those now, protein the other. It absolutely helps me think better and feel better throughout the day. Noticeable when I stop taking it. And its dirt cheap. If I had more disposable income I'd have a few others but I went from tons of supplements to basically nothing. I never use PWOs or anything now, even when I do have money.

            1. red-iron-pine · · focus · HN ↗
              > bodybuilding.com forums.. man, long time ago.

              while they had notable misses like 20g to load, they weren't terribly wrong either, and the forums were -- for a while, anyway -- pretty positive, helpful places.

              early internet meant the worst idiots hadn't gotten there yet.

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