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Creatine uptake enhances antitumor immunity

185 points · 227 comments · lormayna

  1. ThouYS · · focus · HN ↗
    The whole creatine craze reminds me of Vitamin D a couple of years ago. Which also sounded harmless, but can go very wrong if not careful
    1. BugsJustFindMe · · focus · HN ↗
      > but can go very wrong if not careful

      This is vague and doesn't explain anything. Can you share any references that communicate what you're thinking about?

      1. nkozyra · · focus · HN ↗
        They're talking about vitamin D, which accumulates due to being fat soluble and is indeed toxic at a certain level[1]

        It became something of a panacea nutrient, recently around COVID.

        1. <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Vitamin_D_toxicity" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Vitamin_D_toxicity

        1. nomel · · focus · HN ↗
          And, if you drink a glass of carrot juice a day, you&#x27;ll receive toxic levels of vitamin A!

          ~40% of people don&#x27;t get enough vitamin D [1]. It&#x27;s not useful to categorize it as some trend, based on people just not following general recommended dosing (with more precise dosing depending entirely on personal sun exposure and skin color).

          edit: As an office worker, I take 10k IU per day when I&#x27;m entirely indoors (most of the time), but vary it based on sun exposure. I based this on recent studies, and have my doctors approval with an exactly center-of-the-nominal-range vitamin D serum level.

          [1] <a href="https:&#x2F;&#x2F;pmc.ncbi.nlm.nih.gov&#x2F;articles&#x2F;PMC9573946&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pmc.ncbi.nlm.nih.gov&#x2F;articles&#x2F;PMC9573946&#x2F;

          1. xnickb · · focus · HN ↗
            &gt; severe VDD was defined as serum 25(OH)D levels of &lt;25 nmol&#x2F;L, moderate deficiency as 25–50 nmol&#x2F;L, insufficiency as 50–75 nmol&#x2F;L, and sufficiency as &gt;75 nmol&#x2F;L.

            These numbers seem high to me. The 75 nmol&#x2F;L (30ng&#x2F;L) is not really a reliable value. It was published in a research that raises many questions due to conflict of interests.

            Hence the

            &gt; ~40% of people don&#x27;t get enough vitamin D

            becomes:

            &gt; ~40% of people in the USA don&#x27;t get enough vitamin D according to Dr. Holick

            Where I live the norm is 20 ng&#x2F;L and if we apply that, then the shocking 40% becomes more reasonable 10-15%

            1. piltdownman · · focus · HN ↗
              Insufficient in Ireland is also set at 30--50 nmol&#x2F;L (12--20 ng&#x2F;mL).

              Sunlight UVB radiation needed to make vitamin D is only available in Ireland during the months of April through October. This is due to our geographic location 52o - 55o North and means that Ireland experiences a ‘vitamin D winter’ that stretches from the end of October to late March.

              Currently, 94 % of children, 94 % of teenagers and 90 % of adults on the island of Ireland have inadequate vitamin D intakes. Therefore, almost everybody in Ireland needs a supplement of vitamin D and 15 µg (600 IU) is recommended on a daily basis.

              N.B. In the early 2000s, over 20 cases of rickets (a weakening of the bones caused by severe vitamin D deficiency) in infants and toddlers were reported in Ireland.

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