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Creatine uptake enhances antitumor immunity

185 points · 227 comments · lormayna

  1. ThouYS · · focus · HN ↗
    The whole creatine craze reminds me of Vitamin D a couple of years ago. Which also sounded harmless, but can go very wrong if not careful
    1. BugsJustFindMe · · focus · HN ↗
      > but can go very wrong if not careful

      This is vague and doesn't explain anything. Can you share any references that communicate what you're thinking about?

      1. nkozyra · · focus · HN ↗
        They're talking about vitamin D, which accumulates due to being fat soluble and is indeed toxic at a certain level[1]

        It became something of a panacea nutrient, recently around COVID.

        1. <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Vitamin_D_toxicity" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Vitamin_D_toxicity

        1. mhurron · · focus · HN ↗
          Your own link shows that what is considered toxic levels are far higher than most people would expect. Vitamin D toxicity is not that easy to accidentally hit.

          Overdose has been observed at 1,925 μg&#x2F;d (77,000 IU per day). Acute overdose requires between 15,000 μg&#x2F;d (600,000 IU per day) and 42,000 μg&#x2F;d (1,680,000 IU per day) over several days to months.

          1. nkozyra · · focus · HN ↗
            &gt; Your own link shows that what is considered toxic levels are far higher than most people would expect.

            Unless, as mentioned, it had some traction as a cure all around the time of COVID.

            This happens periodically and is again happening with vitamin C (which, whatever, getting to any dangerous amount might be physically impossible).

            1. mhurron · · focus · HN ↗
              Would you mind providing some examples? I can&#x27;t say that I&#x27;m really up on a lot of psudoscience.

              A pretty standard bottle of Vitamin D at 10k IU is 60 capsules&#x2F;pills&#x2F;whatever. That&#x27;s a 2 month supply.

              To hit the toxic eventually (77k IU) you would be going through a 2 month supply every ~7 days. To hit the acute toxicity in days or weeks (low end 600k), your going through that bottle every day.

              However, every single time that someone mentions Vitamin D, people jump out of the woodwork about toxicity without ever actually bringing up just how much you have to take as if if you take the 400 IU capsule, going one IU over is going to kill you. I&#x27;m also pretty sure that a specific group of denialists shouldn&#x27;t be counted as a reason to scream warnings from the mountaintops every time someone thinks about Vitamin D.

              1. nkozyra · · focus · HN ↗
                &gt; Would you mind providing some examples?

                Sure. This is only going to be anecdotal and sparse examples, but this became a thing post-Covid, primarily as a &quot;natural alternative&quot; to vaccination.

                Not just random people on random forums, Joe Rogan several times espoused the value of D along with other usual suspects:

                &quot;Rogan said he started feeling ill on Aug. 28 and tested positive the next day. He added he began taking his regimen the same day, which apparently included ivermectin, IV drips of vitamins D and C, nicotinamide adenine dinucleotide (NAD) that helps repair cells, and monoclonal antibodies. He said he felt fine the next day.&quot;

                &quot;Man Vomits For Months After Taking Vitamin D at Almost 400x Daily Recommended Dose&quot;

                <a href="https:&#x2F;&#x2F;www.news-medical.net&#x2F;news&#x2F;20220706&#x2F;e28098Hypervitaminosis-De28099-is-on-the-rise-and-linked-to-serious-health-issues.aspx" rel="nofollow">https:&#x2F;&#x2F;www.news-medical.net&#x2F;news&#x2F;20220706&#x2F;e28098Hypervitami...

                <a href="https:&#x2F;&#x2F;www.sciencealert.com&#x2F;man-overdoses-vomits-for-months-after-taking-almost-400x-recommended-vitamin-d-dose" rel="nofollow">https:&#x2F;&#x2F;www.sciencealert.com&#x2F;man-overdoses-vomits-for-months...

                Also unsurprisingly happened more often around this time with infants:

                <a href="https:&#x2F;&#x2F;www.frontiersin.org&#x2F;journals&#x2F;pediatrics&#x2F;articles&#x2F;10.3389&#x2F;fped.2022.816965&#x2F;full" rel="nofollow">https:&#x2F;&#x2F;www.frontiersin.org&#x2F;journals&#x2F;pediatrics&#x2F;articles&#x2F;10....

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