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Creatine uptake enhances antitumor immunity

185 points · 227 comments · lormayna

  1. nsbk · · focus · HN ↗
    This is such a crazy substance. I'm 43 and I feel like I have more energy than I have ever had before. I started taking it during recovery from a bad ankle fracture since it helps building muscle mass. Once the ankle was better I took up CrossFit, and kept on taking creatine because why not, it helps replenish ATP so I will be able to give the extra-push when working out, I thought.

    What is blowing my mind though is that at $dayjob my team is going through a crazy crunch to deliver a very strategic project and some of us are pushing 10-12h days often. I'm in hour 12 today for the second day in a row, and my head is not tired at all. Turns out the brain also uses a lot of ATP too, specially during demanding cognitive tasks so I guess it is creatine that is keeping the engine running smoothly even after so many hours.

    I will like once every week or two have a poor night sleep. These days I take twice the dose and I don't feel like I'm sleep deprived at all. Feels like cheating! And apparently no side effects at all so far. Well, maybe I'm working too much.

    1. striking · · focus · HN ↗
      Any tips on GI impact? I pair mine with food and lots of water and it's improved but wondering if there's any more I should be doing
      1. monkpit · · focus · HN ↗
        Some people report less GI distress with creatine HCL but it’s much more expensive.

        The GI issues are caused by the creatine absorbing water. This causes your gut to have more water than usual as it follows the creatine through the works… which causes… urgency.

        The effect diminishes after you’ve been taking a regular dose for a while, even with just monogydrate (not HCL).

        Some people say HCL causes less distress because it doesn’t draw water as much. Others argue that defeats the purpose of taking it.

        Monohydrate is studied to death and proven effective, HCL not so much.

        1. kenhwang · · focus · HN ↗
          The studies I've seen from HCl claim it's more bioavailable too, so you only need 1/3 the dosage compared to honohydrate. That makes the cost pretty comparable.

          But otherwise, I'd agree that monohydrate has significantly more research behind it and I'd default to that if it's tolerable.

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