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Creatine uptake enhances antitumor immunity

185 points · 227 comments · lormayna

  1. ortusdux · · focus · HN ↗
    Are there risks to creatine?
    1. luke5441 · · focus · HN ↗
      I get severe cramping from it (reproducible). All I can find are papers about this being a myth and some reddit threads about other people having this.
      1. kenhwang · · focus · HN ↗
        I get it too if I don't drink a lot more water. So did many people on my sports team.

        Creatine binds to water (making less water available to your muscles) and allows your muscles to work harder (which makes them need more water). So if you're not drinking a lot more water when you're taking creatine, you will get cramps from either dehydration and/or muscle overuse.

        But once you're past the loading phase for creatine and getting sufficient hydration, it's supposed to lessen cramps because the water bound to creatine also becomes available for use again as the creatine is used by the body.

        1. luke5441 · · focus · HN ↗
          Yeah, of course I tried to drink more water. I also tried to ramp up the dose slower.

          But the cramps are really debilitating, as in random back muscle locks up debilitating, so I thought it best to just give up on this.

          1. kenhwang · · focus · HN ↗
            I don't think dosing affects much, as long as you have excess creatine, the extra water requirements are determined by your muscle mass.
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