‹ BackHN Continuity

Thread

Creatine uptake enhances antitumor immunity

185 points · 227 comments · lormayna

  1. ThouYS · · focus · HN ↗
    The whole creatine craze reminds me of Vitamin D a couple of years ago. Which also sounded harmless, but can go very wrong if not careful
    1. BugsJustFindMe · · focus · HN ↗
      > but can go very wrong if not careful

      This is vague and doesn't explain anything. Can you share any references that communicate what you're thinking about?

      1. nkozyra · · focus · HN ↗
        They're talking about vitamin D, which accumulates due to being fat soluble and is indeed toxic at a certain level[1]

        It became something of a panacea nutrient, recently around COVID.

        1. <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Vitamin_D_toxicity" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Vitamin_D_toxicity

        1. kenhwang · · focus · HN ↗
          My doctor added vitamin D test to his patients recurring blood work since the start of COVID, and found out just about all his patients was deficient or near it.

          If you don&#x27;t have a primarily fish based diet or spend hours under direct overhead sunlight every day without a shirt on, you&#x27;re probably deficient as well.

          1. hungryhobbit · · focus · HN ↗
            That&#x27;s a bit of an exaggeration, Vitamin D does not require hours in the sun:

            &gt; Recommendations to Obtain Adequate Amount of Vitamin D.

            &gt; Sun exposure to the face, arms, hands, and legs without sunscreen for 5 to 30 minutes at least twice a week or more between the hours of 10 am and 4 pm

            Source: <a href="https:&#x2F;&#x2F;pmc.ncbi.nlm.nih.gov&#x2F;articles&#x2F;PMC8299926&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pmc.ncbi.nlm.nih.gov&#x2F;articles&#x2F;PMC8299926&#x2F;

            Now that&#x27;s for most people: if you live in Alaska then during the winter maybe you need a litle more or something ... but the point is most people just need a little sun, &lt; 30 minutes twice a week.

            1. kenhwang · · focus · HN ↗
              I&#x27;ll say track and test yourself, since it depends highly on skin tone and weather.

              That study also claims 12-20ng&#x2F;mL 25-hydroxyvitamin D is sufficient. My doctor says the post-COVID studies suggest 75ng&#x2F;mL is closer to optimal, and &lt;30ng&#x2F;mL had been considered deficient for about a decade before COVID.

              Personally I had no problem hitting 20ng&#x2F;mL through sunlight alone and I&#x27;m pretty fair skinned but live somewhere sunny. But I haven&#x27;t been able to get anywhere near 75ng&#x2F;mL even when I&#x27;ve made an effort to increase vitamin D through supplements and exposure to the sun.

            2. srveale · · focus · HN ↗
              For several months of the year, vitamin D synthesis is near zero in latitudes as low as like 40° or 45°. Boston is 42°.

              In Calgary, it&#x27;s almost half the year that you basically cannot rely on the sun at all for vitamin D.

          2. red-iron-pine · · focus · HN ↗
            yeah I&#x27;m in Canada and had a doctor say the same to me.

            basically any patient he did blood work on, that was an office worker, was moderately or seriously deficient.

Open on Hacker News to reply ↗

Unofficial Hacker News client; not affiliated with Y Combinator.