‹ BackHN Continuity

Thread

Why is the liver so weirdly regenerative?

576 points · 293 comments · jbotz

  1. frostysonic · · focus · HN ↗
    I have first-hand experience! My immune system slowly killed my liver (primary sclerosing cholangitis), and I had a transplant. (btw, for $0, thank you to the Australian health system)

    I received a cut-down liver from the donor; I got the bigger lobe, a child recipient got the other lobe.

    Within a few months of transplant, the new liver had regrown, but (probably because of the transplant orientation) rather than growing across to the left, it grew down the side of my body.

    It's all good and functions fine, it's just that now my right-side of my body isn't as 'saggy' as my left because of the area it grew in to.

    It's an amazing organ, and it truly sucks when you don't have a well-functioning one.

    1. ASalazarMX · · focus · HN ↗
      Does this mean a healthy donor could donate a sizable chunk of their liver every year?
      1. frostysonic · · focus · HN ↗
        Possible? yes. Practical, not really. Living liver donors (at least in Australia) are rare, because (unlike kidney donations) it's an extremely risky procedure for a living donor. My donor was a deceased donor, and I'm forever grateful for their (and their family's) decision.
        1. astura · · focus · HN ↗
          There were 709 living donor liver transplants in the United States last year.
          1. SecretDreams · · focus · HN ↗
            2025: 12,344 total (709 from living donors)

            2024: 11,458 total (604 from living donors)

          2. goda90 · · focus · HN ↗
            Wow, I didn't know it was such a small number. I know someone with liver failure due to AATD and amazingly one of his close friends is a match and a healthy non-drinker to boot.
        2. frostysonic · · focus · HN ↗
          Actually, after doing a bit of reading, repeat living donations aren&#x27;t possible because the regenerated liver doesn&#x27;t have the same structure of blood vessels and bile ducts needed for transplant, as well as having the scarring etc from the first transplant. e.g. <a href="https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;askscience&#x2F;comments&#x2F;50hcj4&#x2F;can_i_repeatedly_donate_my_liver_since_it_can&#x2F;" rel="nofollow">https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;askscience&#x2F;comments&#x2F;50hcj4&#x2F;can_i_re...
    2. adamredwoods · · focus · HN ↗
      Hello fellow PSCer! Amazing to hear even partial liver transplants work.
      1. frostysonic · · focus · HN ↗
        Hello! I hope you&#x27;re going ok :)
Open on Hacker News to reply ↗

Unofficial Hacker News client; not affiliated with Y Combinator.