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Why is the liver so weirdly regenerative?

576 points · 293 comments · jbotz

  1. cityofdelusion · · focus · HN ↗
    The author suggests humans are overturned to repairing skin and blood, but I strongly disagree. People with problems with wound healing can face significant disability and mortality. Wound healing allows us to have surgery and close up with simple sutures. A lot of complications post-surgery in humans and other animals are specifically from impaired wound healing capability. It’s a good trade-off: nearly everyone will eventually get cut open by accident or on purpose. The skins ability to heal is so amazing that many types of wounds require nothing other than some cleaning, the body will fully clot, bridge, build, and scar back to most retained function. Wound healing allows us to heal large burns and even simply leave many wounds open to air.

    Complications with healing are pretty brutal. Necrosis, amputation, infection are all common without the built-in cascade we have.

    1. WhiteOwlLion · · focus · HN ↗
      Your liver makes platelets so if your liver function is not optimal, wound healing is harder.

      Some people also have rare diseases where they don’t have clotting factors so require a transfusion of clotting factors before surgery for optimal wound healing.

      1. BigTTYGothGF · · focus · HN ↗
        > Your liver makes platelets

        Megakaryocytes are primarily bone marrow cells.

        1. leereeves · · focus · HN ↗
          Indeed, but your liver does make clotting factors and also thrombopoietin, which stimulates platelet production.
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