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Why is the liver so weirdly regenerative?

576 points · 293 comments · jbotz

  1. card_zero · · focus · HN ↗
    > Evolution decided the good outweighed the bad, and I expect that evolution was right.

    We can expect evolution to do the right thing for the genes. Not for us.

    1. cortesoft · · focus · HN ↗
      I get its just a framework to understand what is happening, but I always hate the phrasing of describing a 'decision' to a process like evolution. There are no decisions being made in the process, just a series of outcomes that lead in a direction
      1. someonebaggy · · focus · HN ↗
        Evolution is literally just the observation that there are lots of things that self-replicate.

        That's it. That's the entire thing. Plus some nuance about things that self-replicate faster than other things...

        It occurs at all levels. Amyloid protein in Alzheimer's patients is self-replicating. So are cells. So are individual parts of cells. Sometimes things replicate by being parts of a larger thing that replicates, sometimes they don't. It's all one big chaotic tangled mess with no particular purpose or design. Human cells evolve, so do humans, so do human societies. So do rocks.

        1. cwillu · · focus · HN ↗
          Rocko can't have kids, because Rocko is just a stupid rock.
          1. card_zero · · focus · HN ↗
            Possibly a reference to A.G. Cairns-Smith, who speculated about evolving clay crystals. (They can sit in a stream and accumulate minerals, and reproduce that way.)
          2. pocksuppet · · focus · HN ↗
            Crystals catalyze their own expansion in a suitable solution.
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