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Claude discovers a novel enzyme system with CRISPR-like repeats

780 points · 805 comments · raahelb

  1. evolarjun · · focus · HN ↗
    It is odd (or maybe not) that they decided to publish a marketing whitepaper rather than a more traditional journal submission + preprint. The work does appear to be sufficient for a publication, though there's a good chance a reviewer will rip into them for some of the assertions they make, but given the topic I'm sure the paper will be accepted regardless.

    The market for entry-level programmers has already declined, but at least they were somewhat in demand and made reasonable salaries. Now what happens to post-docs who already make almost nothing and often get treated like crap?

    1. gavinray · · focus · HN ↗
      Did anyone read the blogpost? They did publish a pre-print:

        > Our work to understand the primary function of ARTs is ongoing. However, we think it is important to share such findings early, both to demonstrate Claude’s capabilities and to give the broader community insight into what we’re working on. We have released a pre-print (here) that discusses this in more detail.
      
      <a href="https:&#x2F;&#x2F;www-cdn.anthropic.com&#x2F;22573675ada52a8ca8a97a1a4b4326b2f208a071.pdf" rel="nofollow">https:&#x2F;&#x2F;www-cdn.anthropic.com&#x2F;22573675ada52a8ca8a97a1a4b4326...
      1. beAbU · · focus · HN ↗
        What&#x27;s with all this pre-print business. It became very prevalent during covid, where it felt like every week some new pre-print was published that discusses some new aspect of the virus. These papers would then be used in arguments and put forward as proof of whatever claim the arguer was making.

        Every man and his dog can publish a pre-print and in my opinion it&#x27;s academically worthless.

        1. sandeepkd · · focus · HN ↗
          I have a similar to pagerank method I use to evaluate such papers. I look for the references to see how many authors are using their own references (past work), the idea being that people do not jump too far, they make incremental progress.

          For the pre-print I could only find only one author who has a single referenced article.

          1. dekhn · · focus · HN ↗
            The pre-print authors all have long publication histories.

            Pagerank was inspired by academic citation networks; it just turned it in a recursive matrix problem (of which there was some prior literature).

            1. sandeepkd · · focus · HN ↗
              &gt; references to see how many authors are using their own references (past work), the idea being that people do not jump too far, they make incremental progress

              The authors are not using their own prior work in the paper, thats the point I was trying to make. I have worked in biotech lab for couple years and its one of the criteria&#x27;s people use to consider some ones work useful and worth the time.

              1. dekhn · · focus · HN ↗
                I think you fundamentally misunderstand both the results published here, and how scientists operating at the highest level of academic research operate. None of these authors has to worry about citing previous work to get the attention of biotech labs.
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