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The Millennium Problems for Biology

164 points · 120 comments · artninja1988

  1. daoboy · · focus · HN ↗
    This is all well outside my area of expertise, but my impression is that Michael Levin's work with bioelectricity is on the cusp of #6 Somatic limb regeneration.

    SMEs please correct the record if I'm mistaken.

    1. jodacola · · focus · HN ↗
      Unfamiliar with Levin’s work, but:

      There’s also this study [0] I read recently, along a different path of using known growth factors and proteins to kick off regeneration.

      [0] <a href="https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41467-026-72066-8" rel="nofollow">https:&#x2F;&#x2F;www.nature.com&#x2F;articles&#x2F;s41467-026-72066-8

      1. gavinray · · focus · HN ↗
        ECM (Extracellular Matrix) has been studied for similar properties:

        <a href="https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.64898&#x2F;2026.08.05.742898v1.full" rel="nofollow">https:&#x2F;&#x2F;www.biorxiv.org&#x2F;content&#x2F;10.64898&#x2F;2026.08.05.742898v1...

        &quot;Extracellular matrix particle treatment induces digit regeneration in soft-tissue preserved amputation (SPA) model of adult mice&quot;

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