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The Millennium Problems for Biology

164 points · 120 comments · artninja1988

  1. rdtsc · · focus · HN ↗
    > Demonstrate the emergence of life from chemical precursors in a laboratory setting

    Wait, isn’t this an already solved problem? I remember in the 90s school books (material written in the 80s-70s likely) it was presented as “so and so did electric discharges in an atmospheric gas mixtures and they got organic molecules” therefore the origins of life is solved. I remember thinking how cool that was. I guess the “therefore” step was sort of a lie if it’s still an open problem…

    1. Metacelsus · · focus · HN ↗
      You're thinking of the Miller-Urey experiment. They got some biomolecules (amino acids, etc) but definitely not life
      1. rdtsc · · focus · HN ↗
        Yeah that's the one. Just looked it up it was it the early 1950s. I guess I was either too impressionable or the textbook and/or teacher cut a few corners because I remember it being presented as "we solved the origins of life already" situation.
    2. NooneAtAll3 · · focus · HN ↗
      biologists got even further - experiments managed to make RNA longer than a different team's self-replicating RNA

      still not all the way to something alive-like

      I recently watched this video on the topic <a href="https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=OsXGgrXwllc" rel="nofollow">https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=OsXGgrXwllc

    3. ricksunny · · focus · HN ↗
      Science was presented in a just-so way in our youth. It still is ( #Scicomms ), but back then, whether reading Junior Scholastic or the margin captions of a high school science textbook handed down ex cathedra, there was no communication pathway to pose vexing questions in a publicly visible way as we do now.

      We don&#x27;t even know if Miller or Urey themselves would have (or did) frame their results that way. The honest framing is &#x27;hey this is one way to form amino acids, and maybe that pathway is reflective of the origin of life, but that supposition remains conjecture on our part.&#x27;

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